Ultraviolet‐B induction of interstitial collagenase and stromelyin‐1 occurs in human dermal fibroblasts via an autocrine interleukin‐6‐dependent loop

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Abstract
Ultraviolet‐B irradiation of human dermal fibroblasts has earlier been shown to induce matrix‐degrading metalloproteinases, thus driving connective tissue degradation in photoaging and photocarcinogenesis. Herein, we report that Ultraviolet‐B irradiation led to a dramatic increase in specific mRNA and protein levels of interstitial collagenase, stromelysin and interleukin‐6. By contrast, the major tissue inhibitor of matrix‐degrading metalloproteinases, TIMP‐1, was unaffected. Monospecific neutralizing antibodies directed against human interleukin‐6 significantly reduced the interstitial collagenase and stromelysin‐1 protein levels. Taken together, our data provide the first evidence that Ultraviolet‐B induction of interstitial collagenase and stromelysin‐1 occurs via the synthesis and release of interleukin‐6. Hence, this newly identified autocrine mechanism may contribute to dermal photodamage.

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