Prednisolone inhibits phagocytosis by polymorphonuclear leucocytes via steroid receptor mediated events
Open Access
- 1 February 1983
- journal article
- research article
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 42 (1) , 56-62
- https://doi.org/10.1136/ard.42.1.56
Abstract
Prednisolone, at concentrations between 2·78 × 10−6 M (1 μg/ml) and 1·39 × 10−8 M (5 × 10−3 μg/ml) exerts an inhibitory effect on the phagocytosis of latex particles by normal human polymorphonuclear leucocytes in vitro as assessed by electron microscopical analysis. This inhibition appears to be receptor-mediated, as it is dependent upon RNA and protein synthesis and is glucocorticoid specific.This publication has 47 references indexed in Scilit:
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