Effects of the Angiotensin I Converting Enzyme Inhibitor Perindopril on Cerebral Blood Flow in Awake Hypertensive Rats

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Abstract
As chronic hypertension shifts the lower limit of cerebral blood flow (CBF) autoregulation to higher pressure levels, we studied the effects of t h e angiotensin converting enzyme (ACE) inhibitor, perindopril on mean arterial pressure (mean BP), basal CBF, and CBF autoregulation in awake renovascular hypertensive (2 kidneys, 1 clip model) and spontaneously hypertensive rats (SHR). Blood pressure was measured via a chronically implanted arterial cannula and CBF b y hydrogen clearance. Chronic renovascular hypertension, like spontaneous hypertension, caused a marked shift in t h e lower limit of CBF autoregulation but did not alter basal CBF. In SHR, acute administration of perindopril did not diminish CBF in spite of the fact that BP fell to a level below the lower limit of CBF autoregulation (determined b y hypotensive hemorrhage). Chronic treatment of renovascular hypertensive rats with perindopril normalized BP and restored CBF autoregulation. Am J Hypertens 1991;4:246S-252S

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