Adriamycin and Daunorubicin Inhibition of Mutant T4 DNA Polymerases

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Abstract
The anticancer drugs, adriamycin and daunorubicin, as well as two other DNA reagents, ethidium bromide and 9-aminoacridine, all exert a differential inhibitory effect on nucleotide incorporation for purified DNA polymerases induced by mutant and wild-type bacteriophage T4. When compared with DNA polymerase of wild-type phage, antimutator enzymes are inhibited to a far greater extent and mutator enzymes to a lesser extent. In contrast, the polymerase-associated 3′-exonuclease activities of wild type and mutants are also inhibited by the compounds but nondifferentially.