Analysis of Immunity in Experimental Tsutsugamushi Disease
Open Access
- 1 February 1952
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 68 (2) , 115-120
- https://doi.org/10.4049/jimmunol.68.2.115
Abstract
Summary: Mice, initially immunized with active rickettsiae and resistant to subsequent inoculation, could not withstand invasion of reinoculated rickettsiae into tissues: that is to say, superinfection is possible in experimental Tsutsugamushi disease. Superinfection occurs whether doses of rickettsiae as large as 105 LD50 or as small as 10 LD50 are used. Reinoculated rickettsiae invade immunized tissues, and persist longer than 180 days.Keywords
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