Staurosporine advances interblastomeric flattening of the mouse embryo
- 1 May 1993
- journal article
- research article
- Published by Cambridge University Press (CUP) in Zygote
- Vol. 1 (2) , 103-112
- https://doi.org/10.1017/s0967199400001362
Abstract
Staurosporine, an inhibitor of protein kinase activity, causes premature intercellular flattening of blastomeres but does not induce their premature polarisation. The flattening induced is calcium dependent, is reversed transiently at mitosis and requires the continuing presence of the drug. Staurosporine also blocks the decompacting effect of phorbol ester on 8-cell embryos.Keywords
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