Multinucleated mammary stromal giant cells. A benign lesion that simulates invasive carcinoma

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Abstract
Multinucleated stromal giant cells were found in breast tissue from 14 patients treated by mastectomy for carcinoma over 3 decades (1950s-1970s). Nine cases were found in a review of 200 consecutive mastectomies (4.5%) performed in 1978. The average age was 51 yr with 9 patients in their 40s. Other than the age distribution, no association with marital status, family history of breast carcinoma, hormone usage, tumor type or stage of disease was observed. This benign lesion of undetermined significance should not be misinterpreted as invasive carcinoma. Multinucleated stromal giant cells were observed in breast specimens from patients not known to have carcinoma at the time of biopsy. These patients had a similar age distribution as those with concurrent carcinoma. Follow-up will be required to determine if the association with carcinoma is significant or merely a coincidence reflecting age or some other unidentified factor.

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