Macromolecular complexes of drugs. I. Doxorubicin-heparin complex.

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Abstract
As a part of our studies to develop anticancer agents with prolonged action and reduced side effects, we examined the macromolecular complex of doxorubicin and heparin. Formation of a complex of doxorubicin and heparin was confirmed by HIAC, infrared, ultraviolet, differential scanning calorimetry, energy micro analysis X-ray and high performance liquid chromatography analysis. If the molecular weight of heparin is assumed to be 9800, one molecule of heparin binds 16 molecules of doxorubicin.