Proton Spin-Lattice Relaxation Studies of Nonmalignant Tissues of Tumorous Mice2

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Abstract
Measurements of the water proton spin-lattice relaxation times in the laboratory frame, T1, showed that many nonmalignant tissues (spleen, kidney, liver, and heart) in mice with a tumor on the hindleg had significantly longer relaxation times than the corresponding tissues in healthy mice. T1 measurements were reported for stomach, intestine, skin, brain, muscle, and lung tissues. Values for animals with a recent (2 days) injection of tumor cells, or with Salmonella infections, were not significantly different from values for the healthy controls in any tissues tested. T1 was significantly longer in samples from tumors themselves than from any other tissue. Preliminary values of the relaxation times in the rotating frame, T1ρ, were reported for all tissues.

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