Biliary excretion of intravenous [14C] omeprazole in humans
- 1 November 1987
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 42 (5) , 504-508
- https://doi.org/10.1038/clpt.1987.188
Abstract
We have studied the biliary excretion of [14C] omeprazole in humans. The study was performed in eight healthy subjects and the technique used was based on multiple marker dilution principles with doublelumen tubes placed in both the stomach and intestine. The results obtained show a 16% biliary excretion of [14C] omeprazole. These data suggest a minimal “spillover” of omeprazole from the gastric mucosa into the gastric lumen in humans. The results also agree with previous data of the fecal recovery of radiolabeled omeprazole that suggest that the fecal excretion of intravenous omeprazole in humans is entirely accounted for by biliary excretion. Clinical Pharmacology and Therapeutics (1987) 42, 504–508; doi:10.1038/clpt.1987.188This publication has 9 references indexed in Scilit:
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