Intrinsic factor antibodies and intrinsic factor mediated vitamin B-12 absorption in pernicious anaemia.
- 1 October 1965
- Vol. 6 (5) , 436-438
- https://doi.org/10.1136/gut.6.5.436
Abstract
Absorption of vitamin B12-Co57, measured by urinary excretion, was potentiated to a greater extent by intrinsic factor preparations from hogs than from humans, in patients with perniciuos anemia. This difference was not found in post-gastrectomy patients. An antibody to human intrinsic factor is postulated to be present in cells of intestinal villi in pernicious anemia.Keywords
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