The antiseptic and trypanocidal action of some benzoylamino quinoline anil and styryl compounds

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Abstract
The anil compounds in which the 6-amino group of the quinoline nucleus is arylated, viz., 2 (p-dimethylamino anil) 6 (p-aminobenzoylamino) quinoline methochloride and the 6 (p-acetylamino benzoylamino) compound, are powerfully antiseptic, preventing growth of staphylococci and colon bacilli in dilutions greater than 1:1,000,000; they are, however, precipitated in high dilution by protein solutions, but retain some trypanocidal action against Trypanosoma brucei in mice and possess low toxicity. The corresponding styryl compounds, though less powerful antiseptics, are highly active, less affected by organic matter, and less toxic, but are not trypanocidal. Several styrylquinoline methoacetate compounds are good trypanocides, 2 (p-acetylamino styryl) 6 (p-aminobenzoyl-amino) quinoline methoacetate being especially reliable. The chemical preparation of each compound is outlined.

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