EFFECT OF MIOTICS ON INTRAOCULAR-PRESSURE OF CONSCIOUS OWL MONKEYS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 15  (10) , 848-851
Abstract
The intraocular pressure of conscious, unsedated owl monkeys (Aotus trivirgatus) was measured with an applanation tonometer. Untreated eyes of the conscious animals had higher values than those reported for owl monkeys anesthetized with pentobarbitone. Locally applied pilocarpine, carbachol and oxotremorine gave concentration-related reductions in pressure, oxotremorine being the most potent and having longer duration of effect than the other compounds. Slight reductions were also observed with aceclidine and RS 86 [spiro-1-methyl-4-pyperidyl-N-ethylsuccinimide hydrochloride]. These results are discussed in relation to the effects of miotics in man.