Embryonal carcinoma antigen and the T/t locus of the mouse.
- 1 November 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (11) , 4080-4084
- https://doi.org/10.1073/pnas.73.11.4080
Abstract
The presence of the [embryonal carcinoma mouse teratoma cell] F9 antigen and 4 other antigens related to the T/t locus of the mouse was investigated by immunofluorescence on implantation embryos. In morulae heterozygous for any of these t haplotypes, both the appropriate t antigen and the F9 antigen are expressed. The F9 embryos homozygous for some (tw32 and tw5) but not for other haplotypes. Whatever the time of action of a t haplotype, its corresponding antigen is apparently expressed during cleavage and the F9 antigen is apparently specified by a gene(s) in the region of the T/t locus.Keywords
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