ACUTE AND CHRONIC ADRENAL INSUFFICIENCY IN A PATIENT SHOWING POLYGLANDULAR DEFICIENCY AND ACROMEGALY

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Abstract
The case reported is that of a 41-year-old man who showed evidence of inactive acromegaly and in whom acute adrenal insufficiency developed. The acute adrenal insufficiency responded to large doses of adrenal cortical extract and to correction of the electrolyte balance. The patient was found to have hypogonadism, evidenced by an atrophic prostate and by testicular biopsy findings which showed atrophy of interstitial tissue and maturation arrest. Hypothyroidism was present, both clinically and as evidenced by a low basal metabolic rate. It is believed that the polyglandular deficiency was on the basis of diminished anterior pituitary function. He was given substitution therapy and improved remarkably. Acute adrenal insufficiency as a sequel to acromegaly is extremely rare, according to reports in the literature.

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