The control of mutational instability by a new mutator gene ofDrosophila melanogaster
- 1 February 1975
- journal article
- research article
- Published by Hindawi Limited in Genetics Research
- Vol. 25 (2) , 163-177
- https://doi.org/10.1017/s0016672300015561
Abstract
SUMMARY: The isolation and genetic characterization of a new mutator gene,Mutator-forked3N(Mu-f3N), ofDrosophila melanogasterare described. This mutator gene is unique in that it seems to increase specifically the reversion frequency of the unstable mutantforked3N(f3N, 1–56.7), since the frequency of spontaneous sex-linked recessive lethals in males and females and the frequency of reverse mutations at eight additional X-linked alleles were unaffected byMu-f3N. The mutator is a dominant gene that has been mapped to the region betweenf3N(1–56.7) andBeadex-2 (Bx2, 1–59.4) in theXchromosome, and it seems to function only in the ‘ cis’ configuration. The mode of action ofMu-f3Nis compared with that of other mutator genes.Keywords
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