INFLUENCE OF THE TROPHOBLAST UPON DIFFERENTIATION OF THE UTERINE EPITHELIUM DURING IMPLANTATION IN THE MOUSE

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Abstract
SUMMARY During the preparation of the uterus for implantation of blastocysts the luminal surface of the epithelial cells undergoes a characteristic differentiation. In non-pregnant animals this can be induced by progesterone and oestrogen, but in pregnant animals the basic hormonal control is augmented by a local effect of the blastocyst. This has been demonstrated by examining the uteri of animals made unilaterally pregnant. The differentiation of the luminal epithelial surface of the fertile horn was in advance of that in the sterile horn. The injection of oil into one horn of the uterus of pseudopregnant animals also accelerated the change in the luminal surface of the injected horn. It is suggested that contact with the cell membrane of the trophoblast influences differentiation of the uterine epithelium and that oil is able to mimic this contact reaction.

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