Mechanism of Digitalis Action on the Heart

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Abstract
FOR almost two hundred years digitalis has been so essential and effective in cardiac therapy that it has been called the most useful drug of all times. Despite widespread and skillful clinical use its primary circulatory actions have become fully established only during the last two decades, and the underlying cellular mechanisms remain uncertain to this day. Few questions in biology have been the subject of such intensive research effort, but many findings are still controversial or conflicting. The following is a brief summary of current thinking in this field. More extensive discussions and pertinent references are included in several . . .

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