SEROTONIN RECEPTORS. I. EXTRACTION AND ASSAY OF A SUBSTANCE WHICH RENDERS SEROTONIN FAT-SOLUBLE
- 15 December 1958
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 44 (12) , 1202-1210
- https://doi.org/10.1073/pnas.44.12.1202
Abstract
A substance was extracted from stomach, colon, brain, spinal cord, and certain other animal tissues by the action of cold fat solvents. This substance has the property of making serotonin soluble in a fat solvent (benzene-butanol) in the presence of Ca ++. A method of assay for the substance was developed which depends on the extraction of serotonin into benzene-butanol from aqueous solution in the presence of the substance, decomposing the extracted complex, and measuring the amount of serotonin liberated. Some indications exist that the substance may be the non-enzymatic portion of the serotonin receptors of smooth muscle and nerve.This publication has 6 references indexed in Scilit:
- A PROBABLE MECHANISM OF ACTION OF SEROTONINProceedings of the National Academy of Sciences, 1958
- Probable Evolutionary Relationship of Serotonin and Indoleacetic Acid, and Some Practical Consequences TherefromNature, 1957
- EVIDENCE FOR THE PARTICIPATION OF SEROTONIN IN MENTAL PROCESSESAnnals of the New York Academy of Sciences, 1957
- THE ESTIMATION OF 5-HYDROXYTRYPTAMINE (SEROTONIN) IN BIOLOGICAL TISSUESJournal of Biological Chemistry, 1955
- DRUGS WHICH ANTAGONIZE 5‐HYDROXYTRYPTAMINEBritish Journal of Pharmacology and Chemotherapy, 1954
- A BIOCHEMICAL AND PHARMACOLOGICAL SUGGESTION ABOUT CERTAIN MENTAL DISORDERSProceedings of the National Academy of Sciences, 1954