NEUTROPHIL MYELOPEROXIDASE - SIMPLE, REPRODUCIBLE TECHNIQUE TO DETERMINE ACTIVITY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 93  (2) , 232-237
Abstract
Neutrophil MPO [myeloperoxidase] deficiency has been rarely documented. This is because of the low incidence of infections in these individuals and the lack of use of various screening techniques which would detect them. Using the Hemalog D, 1 completely deficient and 18 partially deficient subjects were identified. These subjects were studied by staining their peripheral blood smears for MPO and grading the intensity of the stain on 100 consecutive neutrophils (MPO score) and by chemically quantifying the MPO activity. There was an excellent correlation between MPO score and quantitated MPO activity. The MPO score is a simple semiquantitative method to estimate MPO activity.

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