Hexarelin Signaling to PPARin Metabolic Diseases
Open Access
- 2 January 2008
- journal article
- review article
- Published by Hindawi Limited in PPAR Research
- Vol. 2008, 1-9
- https://doi.org/10.1155/2008/364784
Abstract
Investigating the metabolic functions of the nuclear receptor peroxisome proliferator-activated receptor 𝛾 (PPAR𝛾) has been extremely rewarding over the past years. Uncovering the biologic roles of PPAR𝛾 and its mechanism of action has greatly advanced our understanding of the transcriptional control of lipid and glucose metabolism, and compounds such as thiazolidinediones which directly regulate PPAR𝛾 have proven to exhibit potent insulin-sensitizer effects in the treatment of diabetes. We review here recent advances on the emerging role of growth hormone releasing peptides in regulating PPAR𝛾 through interaction with scavenger receptor CD36 and ghrelin GHS-R1a receptor. With the impact that these peptides exert on the metabolic pathways involved in lipid metabolism and energy homeostasis, it is hoped that the development of novel approaches in the regulation of PPAR functions will bring additional therapeutic possibilities to face problems related to metabolic diseases.Keywords
Funding Information
- Canadian Institutes of Health Research
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