ROUTE OF LYMPHOCYTE MIGRATION IN PIGS .1. LYMPHOCYTE CIRCULATION IN GUT-ASSOCIATED LYMPHOID-TISSUE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 42  (3) , 469-474
Abstract
Recirculating lymphocytes originating from the intestine in pigs probably are returned to the blood circulation at the level of the mesenteric lymph nodes (MLN) and not via efferent intestinal lymph. This was demonstrated by 3 observations: removal of all MLN resulted in a 30-fold increase in lymphocyte numbers in efferent lymph of pigs, but not in rats; there are about 25 times more lymphocytes in afferent intestinal lymph than efferent intestinal lymph in normal pigs; 51Cr-labeled lymphocytes injected into afferent lymphatics are mostly recovered in the node tissue or efferent lymph of sheep, and very few in the venous drainage. In pigs relatively few labeled cells are recovered in the node or in efferent lymph. [The intestine and its associated lymphoid tissue is a major site for the recirculation of lymphocytes and generation of lymphoblasts produced in response to enteric antigens.].

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