Glomerulonephritis Induced in Mice by Echo 9 Virus

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Abstract
Two hundred and twenty-two suckling HaM/ICR mice were inoculated with ECHO 9 virus intraperitoneally. The renal lesions were studied by light microscopy, electron microscopy and immunofluorescent technics. Characteristic glomerular lesions resembling acute glomerulonephritis were seen six days after inoculation. The frequency and severity of glomerular lesions increased with time and reached a maximum two to three weeks after inoculation. Later, the lesions decreased in frequency and severity and almost disappeared at six weeks after inoculation, although viral antigen was present up to 54 days. Viral antigen deposits were observed in the glomeruli, indicating that the glomerulonephritis was viral in origin and the result of either direct infection or an antigen-antibody reaction.

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