Inhibition of postprandial pancreatic and biliary secretion by loperamide in patients with short bowel syndrome.
Open Access
- 1 February 1982
- Vol. 23 (2) , 98-101
- https://doi.org/10.1136/gut.23.2.98
Abstract
Patients with the short bowel syndrome are usually afflicted by chronic diarrhoea and treated with opiate drugs, yet little documentation of the effects of such drugs on digestive function is available. In the present study we found that acute oral administration of loperamide resulted in 50% inhibition of postprandial trypsin and bilirubin output in patients with short bowel syndrome. These changes are consistent with an opiate effect.This publication has 24 references indexed in Scilit:
- Reversible Gastric and Pancreatic Hyposecretion after Long-Term Total Parenteral NutritionNew England Journal of Medicine, 1979
- Control of human postprandial pancreatic exocrine secretionDigestive Diseases and Sciences, 1979
- Use of the constant perfusion technique in the nonsteady state.1977
- Gastric Emptying of Solid Food in Normal Man and After Subtotal Gastrectomy and Truncal Vagotomy with PyloroplastyGastroenterology, 1977
- Effect of loperamide on fecal output and composition in well-established ileostomy and ileorectal anastomosisDigestive Diseases and Sciences, 1977
- Effect of analgesic agents on emptying of the gallbladder in manEuropean Journal of Clinical Pharmacology, 1976
- Gastric emptying of liquids in man. Quantification by duodenal recovery marker.1973
- Relations between Pancreatic Enzyme Outputs and Malabsorption in Severe Pancreatic InsufficiencyNew England Journal of Medicine, 1973
- Studies of Gastrointestinal InteractionsScandinavian Journal of Gastroenterology, 1972