Heterogeneity in Paget disease of the bone
- 8 June 2000
- journal article
- research article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 92 (5) , 303-307
- https://doi.org/10.1002/1096-8628(20000619)92:5<303::aid-ajmg2>3.0.co;2-e
Abstract
Paget disease of the bone is a common skeletal disorder. Recently, a gene for Paget disease was localized to 18q with subsequent evidence for linkage heterogeneity. We report the identification and clinical characterization of a large pedigree of Paget disease and demonstrate that the Paget disease gene in this pedigree is not linked to the region on 18q, thus confirming linkage heterogeneity. Am J. Med. Genet. 92:303–307, 2000.Keywords
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