Connectivity-based segregation of the human striatum predicts personality characteristics

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Abstract
The striatum receives projections to a number of cortical and subcortical areas. The authors report here that fiber tracts from prefrontal cortex are correlated with individual differences in reward dependence and that tracts from the hippocampus, amygdala and ventral striatum are correlated with individual differences in novelty seeking. We found that personality characteristics are linked to dissociable connectivity streams in the human brain. Whereas fiber tracts between a subcortical network, including the hippocampus and amygdala, and the ventral striatum predicted individual differences in novelty seeking, tracts between prefrontal cortex and the striatum predicted individual differences in reward dependence. These findings suggest that the strength of limbic-striatal connectivity may, in part, underlie human personality traits.