MALIGNANT FIBROUS HISTIOCYTOMA IN RATS AT SITES OF IMPLANTED MILLIPORE FILTERS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 120  (2) , 207-214
Abstract
Soft-tissue tumors developing in rats at the site of implanted Millipore filters showed the structural, cytochemical and biologic characteristics of malignant fibrous histiocytomas occurring in man. Evidence from this tumor model suggests that malignant fibrous histiocytomas can arise from pluripotential mesenchymal stem cells which are not derived from the mononuclear/phagocytic system and that chronic inflammation and scarring may predispose to their development.