Studies with Hydroxyurea II. Prolonged Exposure of Escherichia coli to Hydroxyurea
- 1 July 1966
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 92 (1) , 178-+
- https://doi.org/10.1128/jb.92.1.178-185.1966
Abstract
Rosenkranz, Herbert S. (Columbia University, New York, N.Y.), and Howard S. Carr . Studies with hydroxyurea. II. Prolonged exposure of Escherichia coli to hydroxyurea. J. Bacteriol. 92: 178–185. 1966.—Concurrent with an inhibition of the synthesis of deoxyribonucleic acid, hydroxyurea devitalized Escherichia coli when exposure to the drug was prolonged to more than 3 hr. Active protein synthesis, but not ribonucleic acid (RNA) production, was a prerequisite for this lethal action. These findings are contrasted to thymineless death, which requires RNA synthesis.This publication has 12 references indexed in Scilit:
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