THE EFFECT OF INSULIN ON SERUM LIPOPROTEINS OF DIABETIC PATIENTS*

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Abstract
Serial serum lipoprotein and cholesterol determinations were performed in 17 female diabetic patients institutionalized because of mental illness. Each patient was studied during prolonged periods of low insulin dosage (hyperglycemic but clinically non-acidotic decontrol phase) and high insulin dosage (control phase). Statistical analysis of the data, based on the assay of more than 300 blood samples over 500 patient-weeks of study, showed highly significant increases in S[image]0-12, s[image]100-400, Atherogenic Index and serum cholesterol values in association with the decontrol phase. Mean increases in s[image]0-12 serum lipoprotein and total cholesterol concentrations associated with the decontrol phase were markedly greater in the younger group of patients, although the mean changes in blood sugar concentration were about the same in the 2 age groups (mean ages, 48 and 71 years). The practical significance of the findings is discussed with respect to the biochemical support they lend to the desirability of rigid rather than loose insulin control of diabetic hyperglycemia. Strict longterm control should result in significant lowering of the incidence of serious sequelae of the atherogenic process.

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