Twenty-Four-Hour Luteinizing Hormone and Follicle-Stimulating Hormone Secretory Patterns in Gonadal Dysgenesis

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Abstract
Plasma LH and FSH concentrations were measured every 20 min for 24 hr in 3 patients with gonadal dysgenesis (12, 18, and 26 yr old). A 12-yr-old girl with Turner's syndrome showed augmented LH and FSH secretory activity synchronous with sleep similar to normal pubertal girls, but with gonadotropin levels in the castrate range. An 18-yr-old girl with pure gonadal dysgenesis had a statistically significant higher mean LH concentration during sleep compared with waking; however, the difference was less striking compared with the 12-yr-old. This diminution in the sleep-wake LH difference is also characteristic of normal late adolescents. A 26-yrold woman with Turner's syndrome did not show increased LH or FSH secretory activity during sleep which is similar to what has been reported in normal women. These findings suggest that patients with gonadal dysgenesis follow a qualitative pattern of gonadotropin secretion during sexual maturation which is similar to normal, but the concentrations of gonadotropins are in the castrate range.

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