The Behavior in the Coombs Test of Anti-A and Anti-B Produced by Immunization with Various Blood Group A and B Substances and by Heterospecific Pregnancy

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Abstract
Summary: Anti-A and anti-B sera from individuals immunized with various blood group substances and by heterospecific pregnancy have been examined by the Coombs test in block titration and by Coombs test after neutralization by blood group substances and found to fall into two groups, one showing enhancement in Coombs titer over the saline agglutinin titer and the other failing to show such enhancement. The results indicate that no proper distinction can be made between such antibodies on the basis of their being “natural” or immune.