Reversibility of Tourniquet Shock With Massive Saline Therapy

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Abstract
Tourniquet shock was produced in rats and allowed to proceed to a terminal phase. Therapy was instituted when the animals were near death. A single large infusion of saline gave temporary improvement and prolonged life, but usually failed to prevent death. Moreover infusions amounting to 8-9% of body weight were sometimes not tolerated. When a huge quantity of saline equal to 15% of body weight was given intravenously ly and intraperitoneally the terminal stage of shock was reversed in 75% of animals. Good results can probably be attributed to elevated tissue tension in the injured leg which reduced further fluid loss, correction of extracellular fluid, and Na deficits, and restoration of adequate blood vol. Reversal of shock state in moribund rats eliminates the presence of an irreversible phase.

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