Experimental Pseudomonas Pneumonia Model in Normal mice
- 1 January 1986
- journal article
- abstracts
- Published by The Japanese Association for Infectious Diseases in Kansenshogaku Zasshi
- Vol. 60 (11) , 1165-1171
- https://doi.org/10.11150/kansenshogakuzasshi1970.60.1165
Abstract
Experimental Pseudomonas pneumonia was induced in normal mice by intratracheal inoculation of P. aerugionosa NC-5. The LD50 of this bacteria was 5.1×106 colony forming units per mouse. The number of bacteria in lungs increased without initial clearance after inoculation of 1×107 colony forming units per mouse and all mice died within 24-48 hours after inoculation. Bacetria appeared in the blood of pneumonia mice 6 hours after inoculation and the number of bacteria in blood increased gradually. Histopathological examination of pneumonia mice showed typical findings of Pseudomonas pneumonia with hemorrhage. The effect of antibiotics such as ceftazidime and gentamicin was evaluated using this murine Pseudomonas pneumonia.Keywords
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