Serum Vitamin B12Content in Liver Disease

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Abstract
THE liver is the principal storage site of vitamin B12 and has an important role in the metabolism of the vitamin. An increased serum content of vitamin B12 found in acute and chronic liver disease has been attributed to the release of the vitamin from the liver owing to hepatic necrosis and to an increased capacity of the serum to bind vitamin B12 as a result of abnormalities in the serum proteins.1 , 2 An increased serum content in acute and chronic myeloid and monocytic leukemia is the result of an increased binding capacity of the serum for vitamin . . .