Antibacterial activity of the anti-inflammatory compound ibuprofen
- 1 February 1995
- journal article
- Published by Oxford University Press (OUP) in Letters in Applied Microbiology
- Vol. 20 (2) , 82-84
- https://doi.org/10.1111/j.1472-765x.1995.tb01291.x
Abstract
The effect of ibuprofen on growth in vitro of six bacterial species was tested. Ibuprofen inhibited growth of the Gram-positive species, but the two Gram-negative species were unaffected. Growth of Staphylococcus aureus was suppressed by ibuprofen concentrations greater than 150 micrograms ml-1 at initial pH 7. At pH 6, such concentrations prevented growth. The antibacterial activity of ibuprofen was affected by pH, being more effective at values below pH 7. Ibuprofen may have an ancillary benefit in topical application, in controlling bacteria.Keywords
This publication has 2 references indexed in Scilit:
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- Determination of Ibuprofen in Ointments by Reversed-Phase Liquid ChromatographyJournal of Pharmaceutical Sciences, 1991