Plasma cGMP and Large Artery Remodeling in Asymptomatic Men
- 1 December 2004
- journal article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 44 (6) , 919-923
- https://doi.org/10.1161/01.hyp.0000145862.33770.e9
Abstract
CGMP regulates vascular smooth muscle tone and arterial wall response to proliferative signals. We determined plasma cGMP and carotid artery intima-media thickness (IMT) and diameter in 84 asymptomatic men submitted to investigation of their cardiovascular risk profiles. Plasma cGMP was positively associated with IMT ( P P P <0.01) and disappeared after cGMP adjustment. This suggests a link between cGMP pathway and arterial wall geometry that is revealed by vascular injury conditions and may participate in early large artery remodeling.Keywords
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