Antigenic Studies on the Psittacosis-Lymphogranuloma Venereum Group of Viruses

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Abstract
Summary: A water-soluble group complement-fixing antigen was efficiently extracted with sodium lauryl sulfate from purified virus suspensions of the psittacosis-lymphogranuloma venereum group. Partial purification was effected by repeated acid precipitation at pH 4.0 to 4.5 which yielded a heat-stable nucleic acid-free antigen composed of protein, carbohydrate and lipid. Treatment of this complex with 5% phenol produced a periodate-sensitive, phenol-insoluble, complement-fixing antigen and a periodate-resistant, phenol-soluble antigen. The phenol precipitate was mainly a lipocarbohydrate and the phenol supernatant fraction was chiefly protein.

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