Reduced Albuminuria After Dietary Protein Restriction in Insulin-Dependent Diabetic Patients With Clinical Nephropathy
- 1 July 1987
- journal article
- clinical trial
- Published by American Diabetes Association in Diabetes Care
- Vol. 10 (4) , 407-413
- https://doi.org/10.2337/diacare.10.4.407
Abstract
Recent clinical investigations have demonstrated that an early restriction of dietary protein intake may reduce the rate of progression of chronic renal failure in humans. In this study the effects of a restricted-protein diet on kidney function in type I diabetic patients with clinical nephropathy were evaluated. Sixteen patients (9 men, 7 women) with mean age 37.1 ± 9.8 yr, mean duration of diabetes 17.7 ± 6.6 yr, proteinuria > 0.5 g/24 h, and serum creatinine concentration of 0.7−1.9 mg/dl were studied. Patients were randomly divided into two groups. The low-protein diet (LPD) group comprised seven patients who were kept for 4.5 ± 1 mo on a diet containing 0.71 ± 0.12 g × kg−1 × day−1 protein. The normal-protein diet (NPD) group comprised nine patients as controls maintained for 11.7 ± 7 mo on their usual diabetic diet containing 1.44 ± 0.12 g × kg−1 × day−1 protein.Keywords
This publication has 0 references indexed in Scilit: