Conservation and Periodicity of DNA Bend Sites in Eukaryotic Genomes
Open Access
- 1 January 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in DNA Research
- Vol. 3 (1) , 25-30
- https://doi.org/10.1093/dnares/3.1.25
Abstract
DNA bend sites appear every 680 bp on average in the human ϵ- and β-globin gene regions. Although most of their molecular nature has not been unraveled, a potential bend core sequence A 2 N 8 A 2 N 8 A 2 (A/A/A) and its complementary T 2 N 8 T 2 N 8 T 2 (T/T/T) appeared preferentially either in or very close to most of the bend sites, whereas other combinations of A 2 and T 2 dinucleotides, A/T/T + A/A/T, T/T/A + T/A/A and A/T/A + T/A/T, did not. The distances between any two of the core sequences in the entire β-globin locus showed a strong bias to a length of 701–800 bp and multiples thereof, suggesting that there is periodicity throughout the locus. This bias was not found for other combinations of A 2 and T 2 . Again, this periodicity was identified in many eukaryotic genes, whereas the tendency was absent in mRNAs and prokaryotic as well as viral genomes.Keywords
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