Time Perception and Hemodialysis

Abstract
A challenging signal-detection procedure may be used to assess neurological function of dialysis patients and other subjects, the degree of uremic toxicity occurring during an interdialytic and the effects of neuroactive drugs. A vigilance task demanding the detection of an irregularly flashing light from a matrix of regularly flashing lights was administered to 3 groups of 15 men: patients undergoing maintenance hemodialysis, patients with chronic illness and no kidney disease and healthy subjects. The procedure yielded a reliable measure; average test-retest correlation was 0.93, which differentiated not only within the hemodialysis cycle, between groups, but was also related to the recency of neuroactive drugs ingested.

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