Loss of synapses in the dentate gyrus of the senescent rat
- 1 January 1976
- journal article
- Published by Wiley in Journal of Anatomy
- Vol. 145 (1) , 129-136
- https://doi.org/10.1002/aja.1001450110
Abstract
Synapses were counted in electron micrographs of the middle third of the molecular layer of the dentate gyrus of Fischer 344 rats, 3 months and 25 months of age. A 27% decrease in the number of synapses was found in senescent animals compared with young adults. This loss of synapses could not be correlated with changes in synaptic size, tissue volume or number of postsynaptic granule cells.Keywords
This publication has 16 references indexed in Scilit:
- Progressive dendritic changes in aging human cortexExperimental Neurology, 1975
- THE DENSITY OF SYNAPSES AND NEURONS IN NORMAL, MENTALLY DEFECTIVE AND AGEING HUMAN BRAINSBrain, 1975
- Axonal regeneration and functional plasticity in the central nervous systemExperimental Neurology, 1974
- Estimation of the number of synapses in a volume of nervous tissue from counts in thin sections by electron microscopyJournal of Neurocytology, 1974
- Fine structural changes in the lateral vestibular nucleus of aging ratsMechanisms of Ageing and Development, 1974
- The inner plexiform layer of the vertebrate retina: A quantitative and comparative electron microscopic analysisJournal of Comparative Neurology, 1970
- Electron microscopic studies of the dentate gyrus of the rat. I. Normal structure with special reference to synaptic organizationJournal of Comparative Neurology, 1966
- Organization of the cerebral cortex. III. A study of aging in the human cerebral cortexJournal of Comparative Neurology, 1955
- Estimation of nuclear population from microtome sectionsThe Anatomical Record, 1946
- Norms for some structural changes in the human cerebellum from birth to old ageJournal of Comparative Neurology, 1920