Serum anti-GM1and anti-GD1aantibodies in patients with motor neuron disease
- 1 December 1992
- journal article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 86 (6) , 599-602
- https://doi.org/10.1111/j.1600-0404.1992.tb05495.x
Abstract
Using an enzyme-linked immunosorbent assay (ELISA) sera from 100 individuals, 20 with motor neuron disease (MND), 25 with peripheral neuropathy (PN), 15 with degenerative dementia and 40 controls, were examined in order to detect serum IgM and IgG anti-GM1 and anti-GD1a antibodies. Patients with MND showed statistically significant higher levels of IgM anti-GM1 antibody compared to the control group. Three patients with peripheral neuropathy had very high levels of anti-GM1 and anti-GD1a antibodies. Antibody levels in patients with degenerative dementia showed no difference compared to the controls. These results suggest that a further inquiry into the role of serum anti-GM1 and anti-GD1a activity in motor neuron disease and peripheral neuropathy is necessary.Keywords
This publication has 24 references indexed in Scilit:
- Lower motor neuron syndromes defined by patterns of weakness, nerve conduction abnormalities, and high titers of antiglycolipid antibodiesAnnals of Neurology, 1990
- Anti-GM1 ganglioside antibodies with differing fine specificities in patients with multifocal motor neuropathyJournal of Neuroimmunology, 1989
- Antibodies to GM1 and GD1b in patients with motor neuron disease without plasma cell dyscrasiaAnnals of Neurology, 1989
- Motor dominant neuropathy and IgM paraproteinemia: the IgM M-protein binds to specific gangliosidesJournal of Neuroimmunology, 1989
- Identification and Characterization of Gangliosides Reacting with IgM Paraproteins in Three Patients with Neuropathy Associated with Biclonal GammopathyJournal of Neurochemistry, 1988
- A treatable multifocal motor neuropathy with antibodies to GM1 gangliosideAnnals of Neurology, 1988
- Motor neuron syndrome and monoclonal IgM with antibody activity against gangliosides GM1 and GD1bAnnals of Neurology, 1988
- Amyotrophic leteral sclerosis: Part 2. EtiopathogenesisAnnals of Neurology, 1985
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984
- Biochemical changes in Dementia disorders of Alzheimer type (AD/SDAT)Neurobiology of Aging, 1983