Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma1
Open Access
- 1 April 2007
- journal article
- Published by Oxford University Press (OUP) in Neuro-Oncology
- Vol. 9 (2) , 135-144
- https://doi.org/10.1215/15228517-2006-038
Abstract
Medulloblastoma is a heterogeneous pediatric brain tumor with significant therapy-related morbidity, its five-year survival rates ranging from 30% toKeywords
This publication has 37 references indexed in Scilit:
- Genome-Wide Analysis of Epigenetic Silencing Identifies BEX1 and BEX2 as Candidate Tumor Suppressor Genes in Malignant GliomaCancer Research, 2006
- Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancerOncogene, 2006
- Neurocognitive Consequences of Risk-Adapted Therapy for Childhood MedulloblastomaJournal of Clinical Oncology, 2005
- A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformationCarcinogenesis: Integrative Cancer Research, 2004
- Statistical significance for genomewide studiesProceedings of the National Academy of Sciences, 2003
- Advances in the Diagnosis, Molecular Genetics, and Treatment of Pediatric Embryonal CNS TumorsThe Oncologist, 2003
- An Epigenetic Approach for Finding Tumor SuppressorsCell Cycle, 2003
- Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNAOncogene, 2002
- Dickkopf1 Is Required for Embryonic Head Induction and Limb Morphogenesis in the MousePublished by Elsevier ,2001
- Somatic mutations ofWNT/wingless signaling pathway components in primitive neuroectodermal tumorsInternational Journal of Cancer, 2001