Impaired Postnatal Development in C/EBP.BETA.-deficient Mice
- 1 January 2006
- journal article
- Published by Japanese Society of Animal Reproduction in The Journal of Reproduction and Development
- Vol. 52 (5) , 645-649
- https://doi.org/10.1262/jrd.17093
Abstract
Tail DNA genotyping of fetal and neonatal mice from C/EBPbeta heterozygous parents was performed to determine whether the decreased number of surviving C/EBPbeta mutants was caused by prenatal or postnatal death. Eighty-four 3-week-old mice born of heterozygous parents had significantly lower numbers of C/EBPbeta-deficient offspring than the expected Mendelian ratio (29.8%+/+, 65.5%+/-, 4.76%-/-, P0.05). No difference in the proportions by sex could be detected in these perinates. This data indicates that C/EBPbeta-deficient mice have unknown lethal problems between the embryonic stage and weaning.Keywords
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