Peripheral neuropathy in Creutzfeldt-Jakob disease

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Abstract
Antoine et al. [1] and Neufeld et al. [2] reported features of a demyelinating peripheral neuropathy in cases of Creutzfeldt-Jakob disease (CJD) associated with a mutation at codon 200 of the prion protein gene. We document a further case of CJD presenting with peripheral neuropathy. In our patient, sequencing the PrP gene revealed no mutations and this case was an example of sporadic CJD. The patient was a 63-year-old man who was first seen on March 6, 1991. He first noticed slight numbness in his toes and fingers in October 1990, and by Christmas 1990, after a long drive, his feet became somewhat numb to the instep bilaterally and pain was noticed at night. In late January 1991, he noticed slight dizziness when he moved suddenly, but this …

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