Extreme Hyperglobulinemia in Subacute Hepatic Necrosis

Publisher Website
Google Scholar
Abstract
SERUM protein disturbance has been recognized in liver disease since Jolies,1 in 1902, first described depression of the whole-blood proteins in cirrhosis. Several years later, Gilbert and Chiray2 and Grenet3 observed this to be due to serum protein depression. In 1925 Filinski4 showed that the serum protein abnormality in cirrhosis included not only albumin depression but also globulin elevation. Subsequent observations5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 have shown these findings to be so common in intrinsic liver disease that the opinion has been advanced12 , 22 that the diagnosis of cirrhosis should be held in doubt in the absence of serum globulin elevation. While for prognostic value . . .

This publication has 33 references indexed in Scilit: