Antisense Pharmacodynamics: Critical Issues in the Transport and Delivery of Antisense Oligonucleotides
- 1 January 1999
- journal article
- review article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 16 (4) , 494-502
- https://doi.org/10.1023/a:1011958726518
Abstract
This review critically examines current understanding of the kinetics and biodistribution of antisense oligonucleotides, both at the cellular level and at the level of the intact organism. The...Keywords
This publication has 99 references indexed in Scilit:
- Cationic Liposomes Coated with Polyethylene Glycol As Carriers for OligonucleotidesJournal of Biological Chemistry, 1998
- Antisense raf oligodeoxyribonucleotide is protected by liposomal encapsulation and inhibits Raf-1 protein expression in vitro and in vivo: implication for gene therapy of radioresistant cancerGene Therapy, 1997
- Pharmacology of Therapeutic OligonucleotidesAntisense and Nucleic Acid Drug Development, 1997
- Characterization of Complexes of Oligonucleotides with Polyamidoamine Starburst Dendrimers and Effects on Intracellular DeliveryJournal of Pharmaceutical Sciences, 1997
- Antisense—Protein Kinase A: A Single-Gene-Based Therapeutic ApproachAntisense and Nucleic Acid Drug Development, 1997
- Comparative Pharmacokinetics, Tissue Distribution, and Tumor Accumulation of Phosphorothioate, Phosphorodithioate, and Methylphosphonate Oligonucleotides in Nude MiceAntisense and Nucleic Acid Drug Development, 1997
- DNA antisense therapy for asthma in an animal modelNature, 1997
- Progress in Antisense Oligonucleotide TherapeuticsAnnual Review of Pharmacology and Toxicology, 1996
- Analysis of Antisense Oligonucleotides by Capillary Electrophoresis, Gel-Slab Electrophoresis, and HPLC: A ComparisonAntisense and Nucleic Acid Drug Development, 1996
- hnRNP PROTEINS AND THE BIOGENESIS OF mRNAAnnual Review of Biochemistry, 1993