Prevalence and significance of asymmetric septal hypertrophy in hypertension: an echocardiographic and clinical study

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Abstract
To assess the prevalence of asymmetric septal hypertrophy (ASH) in hypertensive patients, 613 echocardiographic examinations performed over a period of one year were reviewed. Asymmetric septal hypertrophy (defined by an echocardiographic interventricular septum to left ventricular free wall thickness ratio of ≥ 1·3 and by the presence of suggestive two-dimensional echocardiographic abnormalities) was found in 28 patients (5%) Clinical characteristics of asymmetric septal hypertrophy were assessed in 101 patients who underwent a complete evaluation. Patients with asymmetric septal hypertrophy (n = 9) were compared with patients with echocardiographic symmetrical left ventrical hypertrophy (n = 38) and without left ventricular hypertrophy (n = 54). Our results indicate that neither the severity of hypertension, nor the renin-angiotensin system nor sympathic nerve activity appear to be the primary determinants in the development of asymmetric septal hypertrophy.

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