Synthese von 2-(1′-Amino-1′-substituiertem alkyl)-benzimidazol aus Aminosäuren und Ihre Biologische Aktivität

Publisher Website
Google Scholar
Abstract
N-Blocked amino acids were condensed with o-phenylene diamine in the presence of DCC at 0°C to give derivatives of monoacyl-o-phenylene diamine. The ring closure of monoacyl derivatives thus obtained was then carried out by refluxing them for 10–200 min in toluene, xylene or acetic acid. The dehydrating cyclization by triphenylphosphine was suitable for glutamine, asparagine, and threonine. By these methods, the carboxyl group of naturally occurring amino acids was all cyclized to benzimidazole-ring. Among these new compounds, there are some biological active compounds as regulators for growth of plants or fungi.

This publication has 3 references indexed in Scilit: