CYCLIC FUNCTION IN OVARIAN GRAFTS

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Abstract
SUMMARY Subcutaneous ovarian grafts, which maintained the vaginal cycle in ovariectomized rats for periods up to 12 weeks, were examined histologically to determine whether or not they showed normally ovulating follicles. It was found that ovulation occurred regularly in most autografts, but only in about half the homografts. The homografts included 7- to 10-day ovaries implanted into immature or adult hosts and also similar ovaries frozen and thawed before implantation. Absence of normal ovulation in many homografts, which are often less well vascularized than autografts, may be attributed to an inadequate or unbalanced supply of pituitary gonadotrophins. Degenerative changes indicated by lymphocyte infiltration, are variable in onset, severity and duration, and their progress seems to be unaffected by gonadotrophic stimulus. Only in five out of forty-six hosts were degenerative changes in the graft associated with cessation of vaginal cornification during the experimental period.

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